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KMID : 0387420080190020077
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Korean Society of Oriental Neuropsychiatry
2008 Volume.19 No. 2 p.77 ~ p.93
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The Effects of ChenwhangBosindan(CBD) Hot Water Extract & Ultra-fine Powder on the Alzheimer’s Disease Model
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Choi Kang-Wook
Jung In-Chul
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Abstract
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Objective : This experiment was designed to investigate the effect of the CBD hot water extract & ultra-fine Powder on Alzheimer’s Disease Model Induced by .
Method : The effects of the CBD hot water extract on expression of interleukin-1 beta(), mRNA and production of IL-6, in BV2 microglial cell line treated by lipopolysacchaide(LPS). The effects of the CBD hot water extract & ultra-fine powder on (1) the behavior (2) expression of , tumor necrosis factor-alpha(), (3) the infarction area of the hippocampus in Alzheimer’s diseased mice induced with were investigated.
Result : The CBD hot water extract suppressed the expression of , mRNA in BV2 microglia cell line treated with LPS. The CBD hot water extract significantly suppressed the production of , in BV2 microglial cell line treated with LPS. The CBD hot water extract & ultra-fine powder a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer’s disease induced by in the Morris water maze experiment, which measured step-through latency and distance movement-through latency. The CBD hot water extract & ultra-fine powder significantly suppressed the expression of and protein in the microglial cell of mice with Alzheimer’s disease induced by . The CBD hot water extract & ultra-fine powder suppressed the over-expression of AChE activity in the serum of the mice with Alzheimer’s disease induced by . The CBD hot water extract & ultra-fine powder reduced infarction area of hippocampus, in the mice with Alzheimer’s disease induced by .
Conclusions : These results suggest that the CBD hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer’s disease. Investigation into the clinical use of the CBD hot water extract & ultra-fine powder for Alzheimer’s disease is suggested for future research.
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KEYWORD
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Alzheimer’s disease, ChenwhangBosimDan(CBD), hot water extract & ultra-fine powder
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